Review on Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of Medicinal Applications and Approaches on Estimating its Resource Potential.

@article{Balandaykin2015ReviewOC,
  title={Review on Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of Medicinal Applications and Approaches on Estimating its Resource Potential.},
  author={M. E. Balandaykin and I. Zmitrovich},
  journal={International journal of medicinal mushrooms},
  year={2015},
  volume={17 2},
  pages={
          95-104
        }
}
This paper presents a review of the realm of medicinal applications of Inonotus obliquus raw materials, sterile conks I. obliquus, based on the bibliographies of chemical studies of the fungus. The experimental part of the paper is devoted to the presentation of methods of estimating the resource potential of this fungus based on data obtained in the comfort zone of ththis species. A new form, I. obliquus f. sterilis, is formally described. 
Inoculation success of Inonotus obliquus in living birch (Betula spp.)
TLDR
Despite successful inoculation, the formation of conks was found to be a slow process, and the cultivation of I. obliquus may be difficult to integrate into the management of commercial forests, although set-aside, low-productive birch, especially B. pubescens stands, can be recommended for utilization in its cultivation. Expand
Cultivation of Phellinus spp. for Bioactive Compound Production
Absract In Thailand, mushroom is reported in the traditional Thai medicine. Using of the name “Kratinphiman” covers the genus Phellinus sp. There are many species and different names, It is not clearExpand
Structure elucidation of a new triterpene from Inonotus obliquus.
TLDR
A new triterpene was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5), and compounds 2-4 significantly reduced LPS-induced nitric oxide production to 4.5 ± 0.8%, respectively. Expand
Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction
Abstract Chaga mushroom (Inonotus obliquus) is mainly consumed as an extract. Hot water extraction, which is a traditional method preparing chaga mushroom extract, has limitations requiring a largeExpand
Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.
TLDR
The diverse bioactive metabolites in I. obliquus possess the potential to reduce incidence of tumorigenesis in healthy people and exhibit immunomodulatory potential to restore the compromised immunity and protect against ulcerative damage of GI tract caused by chemotherapy. Expand
Chaga and its bioactive complexes: history and perspectives
A review of research field related to well-known Russian medicinal fungal material, Chaga, is caused by the need to summarize information about the effects of its individual compounds on molecularExpand
Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity
TLDR
The findings suggest the potential application of MeshimaMax for cancer prevention and as supplement regimen for anticancer chemotherapy, probably functioning through activation of innate immunity, which may benefit cancer patients as an alternative supplement. Expand
Mushrooms Integrative Treatment with Inonotus obliquus and Ganoderma lucidum in a Triple Negative Breast Cancer Patient: A Case Report
TLDR
A woman affected by triple-negative breast cancer who used Inonotus obliquus and Ganoderma lucidum during her treatment and preclinical data show cytotoxicity against breast cancer cells are described. Expand
Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells.
TLDR
These findings provide experimental evidence supporting the potential application of I. obliquus in lung cancer treatment and reveal the molecular basis underlying its cytotoxic activity against human lung cancer cells. Expand
Biogenesis of macrofungal sclerotia: influencing factors and molecular mechanisms
TLDR
The molecular mechanisms controlling macrofungal sclerotia formation, including oxidative stress, signal transduction, and gene expression regulation (differential expression of important enzyme or structural protein genes), have been revealed. Expand
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References

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Physicochemical Properties of Melanins Produced by the Sterile Form of Inonotus obliquus(“Chagi”) in Natural and Cultivated Fungus
Physicochemical properties of pigments isolated from the naturally occurring sterile form of Inonotus obliquus(Fr.) Pil. known as Chagi and comprising the major constituent of the medicine befunginExpand
Identification of Inonotus obliquus and Analysis of Antioxidation and Antitumor Activities of Polysaccharides
TLDR
The results indicate that I. obliquus polysaccharides exhibit high antitumor and antioxidation effects, which will enable large-scale production of the poly Saccharides. Expand
A new species of Inonotus (Hymenochaetaceae) from Scandinavia
TLDR
A survey is presented of the species of Inonotus growing in trunk cavities and beneath the bark, and a classification of the setae is proposed. Expand
Sterol composition in field-grown and cultured mycelia of Inonotus obliquus.
TLDR
It is suggested that the sterol composition in mycelia of the fungus can be diversified by supplementing substances inhibiting enzymatic process towards the synthesis of ergosterol. Expand
Antimitotic activity of aqueous extracts of Inonotus obliquus.
The cytotoxic effect of two aqueous extracts of Inonotus obliquus on human cervical uteri cancer cells (Hela S3) in vitro was evaluated. It was concluded that Inonotus extracts at a concentration ofExpand
Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus
TLDR
The results strongly suggest the great potential of the aqueous extract from Inonotus obliquus as immune enhancer during chemotherapy. Expand
Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (persoon) Pilat].
TLDR
The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves, and two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. Expand
Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.
TLDR
It is shown that the 3beta-hydroxy-lanosta-8, 24-dien-21-al and inotodiol components of Inonotus obliquus bear antimutagenic and antioxidative activities. Expand
Oxidative stress response of Inonotus obliquus induced by hydrogen peroxide.
TLDR
Although enhanced HA production occurred after melanogenesis inactivation, total extracellular polyphenol levels were reduced, and these findings suggest that enzymatic activities convert superoxide to H(2)O(2), and non-enzymatic mechanisms are largely responsible for detoxifying H( 2)O (2). Expand
Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus
TLDR
It is shown that coculture of I. obliquus with Phellinus punctatus resulted in less production of mycelial biomass but an increased accumulation of phenolic compounds, melanins, and lanostane-type triterpenoids. Expand
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