Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke.

@article{Walters2009ReviewOT,
  title={Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke.},
  author={Arthur Scott Walters and David B. Rye},
  journal={Sleep},
  year={2009},
  volume={32 5},
  pages={589-97}
}
Evidence is reviewed documenting an intimate relationship among restless legs syndrome (RLS) / periodic limb movements in sleep (PLMS) and hypertension and cardiovascular and cerebrovascular disease. Sympathetic overactivity is associated with RLS/PLMS, as manifested by increased pulse rate and blood pressure coincident with PLMS. Causality is far from definitive. Mechanisms are explored as to how RLS/PLMS may lead to high blood pressure, heart disease, and stroke: (a) the sympathetic… CONTINUE READING

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