Review of the paper

@inproceedings{anonymous2018ReviewOT,
  title={Review of the paper},
  author={anonymous},
  year={2018}
}
  • anonymous
  • Published 16 July 2018
  • Environmental Science
The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients A b s t r a c t In recent years, the two adjacent novel EVER1 and EVER2 genes have been identified, whose mutations are responsible for the development of epidermodysplasia verruciformis (EV). Epidermodysplasia verruciformis is a rare, autosomal recessive genodermatosis associated with increased risk of skin carcinoma. Up to now 7… 
View via Publisher
doi.org

Figures and Tables from this paper

2 Citations

Jujube and green tea extracts protect human fibroblast cells against UVB-mediated photo damage and MMP-2 and MMP-9 production

It is suggested that jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging and can be suggested as a potential candidate for the development of new anti-UVB medicines and cosmetic products.

New Antitumoral Pharmacological Strategies Involving Ca2+/Camp Signaling Pathways

This review addresses the relevance of cyclic nucleotides such as cAMP, and Ca2+ channels in tumor cells, emphasizing the possibility of combined pharmacological interventions which interfere with these intracellular signaling pathways.

References

SHOWING 1-10 OF 387 REFERENCES

A homozygous nonsense mutation in the EVER2 gene leads to epidermodysplasia verruciformis

A homozygous C→T transition at nucleotide position 568 within exon 6 of the EVER2 gene was detected, which led to a premature translation termination and the predicted protein lacked 537 amino acids, the first mutation reported in Chinese patients with EV.

Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis

The identification of nonsense mutations in two adjacent novel genes, EVER1 and EVER2, that are associated with the disease are reported and have features of integral membrane proteins and are localized in the endoplasmic reticulum.

Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis

Polymerase chain reaction and DNA sequencing analysis is employed to characterize the EVER1 gene in a 65-year-old Japanese EV patient to identify two novel mutations, including a nonsense mutation and a premature termination codon.

Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis.

Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses.

  • G. Orth
  • Biology
    Seminars in immunology
  • 2006

Epidermodysplasia Verruciformis in a HIV-Positive Patient Homozygous for the c917A→T Polymorphism in the TMC8/EVER2 Gene

The hypothesis that the combination of immunodeficiency and a susceptibility allele may contribute to the differences in occurrence of EV in HIV-positive patients is supported.

Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod.

Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis.

  • G. Orth
  • Biology
    Current topics in microbiology and immunology
  • 2008
Keratinocytes, the home cells of HPVs, are likely to play a central role in both EV and HPV-5 infections, and the transmembrane viral E5/E8 and cellular EVER proteins interact both with the zinc transporter ZnT1, and arelikely to modulate zinc homeostasis.

A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus.

Taking EV as a model to identify a locus underlying the susceptibility to HPV infections, a genome-wide search for linkage with 255 microsatellite genetic markers in three consanguineous EV families comprising six patients was performed, using the homozygosity mapping approach.

Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis.

EV is an autosomal recessive disease which usually begins in infancy or childhood, with an average age of onset of 9. Flat warts are most common, but pityriasis-like warts occur in approximately 75%…
...