Review of the paper

@inproceedings{anonymous2018ReviewOT,
  title={Review of the paper},
  author={anonymous},
  year={2018}
}
  • anonymous
  • Published 16 July 2018
  • Environmental Science
The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients A b s t r a c t In recent years, the two adjacent novel EVER1 and EVER2 genes have been identified, whose mutations are responsible for the development of epidermodysplasia verruciformis (EV). Epidermodysplasia verruciformis is a rare, autosomal recessive genodermatosis associated with increased risk of skin carcinoma. Up to now 7… 

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A homozygous C→T transition at nucleotide position 568 within exon 6 of the EVER2 gene was detected, which led to a premature translation termination and the predicted protein lacked 537 amino acids, the first mutation reported in Chinese patients with EV.

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The identification of nonsense mutations in two adjacent novel genes, EVER1 and EVER2, that are associated with the disease are reported and have features of integral membrane proteins and are localized in the endoplasmic reticulum.

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Keratinocytes, the home cells of HPVs, are likely to play a central role in both EV and HPV-5 infections, and the transmembrane viral E5/E8 and cellular EVER proteins interact both with the zinc transporter ZnT1, and arelikely to modulate zinc homeostasis.

A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus.

Taking EV as a model to identify a locus underlying the susceptibility to HPV infections, a genome-wide search for linkage with 255 microsatellite genetic markers in three consanguineous EV families comprising six patients was performed, using the homozygosity mapping approach.

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EV is an autosomal recessive disease which usually begins in infancy or childhood, with an average age of onset of 9. Flat warts are most common, but pityriasis-like warts occur in approximately 75%
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