Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic non-cancer pain: tapentadol, a step toward a solution?

@article{Candiotti2010ReviewOT,
  title={Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic non-cancer pain: tapentadol, a step toward a solution?},
  author={K. Candiotti and M. Gitlin},
  journal={Current Medical Research and Opinion},
  year={2010},
  volume={26},
  pages={1677 - 1684}
}
Abstract Objective: Opioids are among the most effective and potent analgesics currently available. Their utility in the management of pain associated with cancer, acute injury, or surgery is well recognized. However, extending the application of opioids to the management of chronic non-cancer pain has met with considerable resistance. This resistance is due in part to concerns related to gastrointestinal and central nervous system-related adverse events as well as issues pertaining to… Expand
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