Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

@inproceedings{Morris2011ReviewOT,
  title={Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration},
  author={Carrie Ann Morris and Stephan Duparc and Isabelle Borghini-Fuhrer and Donald Jung and Chang-Sik Shin and Lawrence L. Fleckenstein},
  booktitle={Malaria Journal},
  year={2011}
}
Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolite dihydroartemisinin (DHA). In this article, a comprehensive review is presented of AS clinical pharmacokinetics following administration of AS by the intravenous (IV… CONTINUE READING
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