Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck.

@article{Blitzer2014ReviewOT,
  title={Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck.},
  author={Grace C. Blitzer and Molly A. Smith and Stephen L. Harris and Randall J. Kimple},
  journal={International journal of radiation oncology, biology, physics},
  year={2014},
  volume={88 4},
  pages={761-70}
}
Human papillomavirus (HPV), a known etiology of a subset of head-and-neck squamous cell carcinomas (HNCs), causes numerous alterations in normal cellular functions. This article reviews the biology, detection, and treatment of HPV-positive HNC. The role of HPV oncoproteins in tumor development, the natural history of HPV infection, and risk factors for and prevention of transmission of oral HPV are considered. Commonly used methods for detecting HPV infection, including limitations of these… CONTINUE READING
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