Review of the Y chromosome and hypertension.

@article{Ely2000ReviewOT,
  title={Review of the Y chromosome and hypertension.},
  author={Daniel L Ely and Monte E. Turner and Amy Milsted},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2000},
  volume={33 6},
  pages={679-91}
}
The Y chromosome from spontaneously hypertensive rats (SHR) has a locus that raises blood pressure 20-25 mmHg. Associated with the SHR Y chromosome effect is a 4-week earlier pubertal rise of testosterone and dependence upon the androgen receptor for the full blood pressure effect. Several indices of enhanced sympathetic nervous system (SNS) activity are also associated with the SHR Y chromosome. Blockade of SNS outflow reduced the blood pressure effect. Salt sensitivity was increased by the Y… CONTINUE READING

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