Review of the Innate Immune Response in Acne vulgaris: Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses

@article{Kim2005ReviewOT,
  title={Review of the Innate Immune Response in Acne vulgaris: Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses},
  author={Jenny Kim},
  journal={Dermatology},
  year={2005},
  volume={211},
  pages={193 - 198}
}
  • Jenny Kim
  • Published 2005
  • Medicine, Biology
  • Dermatology
Acne vulgaris is a common disorder that affects 40–50 million people in the USA alone. The pathogenesis of acne is multifactorial, including hormonal, microbiological and immunological mechanisms. One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes; yet, the molecular mechanism by which P. acnes induces inflammation is not known. Recent studies have demonstrated that microbial agents trigger cytokine responses via Toll-like receptors (TLRs). TLRs are… Expand
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298 Citations

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Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes.
Tumour Necrosis Factor Alpha-induced Protein 3 Negatively Regulates Cutibacterium acnes-induced Innate Immune Events in Epidermal Keratinocytes.
Role of Cytokines in the Pathogenesis of Acne
Toll‐like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni‐ bacterium acnes
Curcumin suppresses interleukin‐6 production in THP‐1 monocytes induced by Propionibacterium acnes extracts via downregulation of Toll‐like receptor 2 expression and the nuclear factor kappa B pathway
  • C. Xu, R. Zeng, +5 authors M. Li
  • Chemistry, Medicine
  • The British journal of dermatology
  • 2019
The protective effects of melittin on Propionibacterium acnes-induced inflammatory responses in vitro and in vivo.
In vitro modulation of TLR‐2, CD1d and IL‐10 by adapalene on normal human skin and acne inflammatory lesions
Establishment of an Anti-acne Vulgaris Evaluation Method Based on TLR2 and TLR4-mediated Interleukin-8 Production
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References

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