Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits

@article{Connolly2015ReviewOS,
  title={Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits},
  author={Siobhan Connolly and Elizabeth A. Heron},
  journal={Briefings in bioinformatics},
  year={2015},
  volume={16 3},
  pages={429-48}
}
The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects have been identified through a variety of mechanisms and a number of statistical methodologies for their detection have been proposed, in particular for genome-wide association studies (GWAS). GWAS have had limited success in explaining the heritability of many complex… CONTINUE READING
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