Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis.

@article{Steinbach2003ReviewON,
  title={Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis.},
  author={William J Steinbach and David A Stevens},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 Suppl 3},
  pages={S157-87}
}
The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal. Previously there were only 2 antifungals with activity against Aspergillus, but over the last few years there has been an explosion of newer agents and reformulations of older antifungals. Exploration has also begun with immunotherapy, with use of cytokines and granulocyte transfusions alone or in combination with antifungal therapy. This review will detail the available in vitro, in vivo, and clinical… CONTINUE READING