Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: A case study using alkyl phthalates.

@article{Caldwell1999ReviewOM,
  title={Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: A case study using alkyl phthalates.},
  author={Daniel J. Caldwell},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1999},
  volume={30 1},
  pages={
          45-53
        }
}
Elevated incidences of mononuclear cell leukemia (MNCL) have been observed in a number of chronic bioassays in the F-344 rat. As this tumor type is unique to the rat and is only common in the F-344 strain, its significance for human cancer risk is unclear. For this reason, a survey of the published literature was undertaken to assess the occurrence and etiology of MNCL in F-344 rats and to evaluate its potential significance to humans using alkyl phthalate data as an example. It was found that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 citations