Review of macrolides and ketolides: focus on respiratory tract infections.

  title={Review of macrolides and ketolides: focus on respiratory tract infections.},
  author={George G Zhanel and Michael H Dueck and Daryl J. Hoban and Lavern M. Vercaigne and John M. Embil and Alfred S. Gin and James A Karlowsky},
  volume={61 4},
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-membered ring macrolides such as clarithromycin and the azalide, azithromycin, have been developed to address the limitations of erythromycin. The main structural component of the macrolides is a large lactone ring that varies in size from 12 to 16 atoms. A new group of 14-membered macrolides known as the… CONTINUE READING


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