Review of macrolides and ketolides: focus on respiratory tract infections.

@article{Zhanel2001ReviewOM,
  title={Review of macrolides and ketolides: focus on respiratory tract infections.},
  author={George G Zhanel and Michael H Dueck and Daryl J. Hoban and Lavern M. Vercaigne and John M. Embil and Alfred S. Gin and James A Karlowsky},
  journal={Drugs},
  year={2001},
  volume={61 4},
  pages={
          443-98
        }
}
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-membered ring macrolides such as clarithromycin and the azalide, azithromycin, have been developed to address the limitations of erythromycin. The main structural component of the macrolides is a large lactone ring that varies in size from 12 to 16 atoms. A new group of 14-membered macrolides known as the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

Similar Papers

Loading similar papers…