Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia

  title={Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia},
  author={C Ervin Davis and Dilip V. Jeste and Lisa T. Eyler},
  journal={Schizophrenia Research},

Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review.

The results of the studies reviewed suggest that the use of clozapine is associated with distinctive structural and functional neuroimaging findings that are not shared with other antipsychotics.

Deconstructing psychosis with human brain imaging.

This review synthesizes the current knowledge on the neurobiology of psychosis from an array of in vivo brain-imaging studies and consistently replicated associations of psychotic symptoms and cognitive impairment in both structural and functional imaging in schizophrenia but not in bipolar disorder.

Methodological and conceptual issues in functional magnetic resonance imaging: applications to schizophrenia research.

The biophysical principles underlying functional MRI are presented, and methodological limitations of the method are discussed, and artifacts related to baseline effects-especially those associated with medication, caffeine, and nicotine use are presented.

Use of magnetic resonance imaging in tracking the course and treatment of schizophrenia

MRI studies have demonstrated structural and functional brain abnormalities, predominantly involving the frontal and temporal lobes, in schizophrenia, and there is, growing evidence for treatment-related neural changes in schizophrenia.

Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

An overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia is provided and the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment are discussed.

Are structural brain changes in schizophrenia related to antipsychotic medication? A narrative review of the evidence from a clinical perspective

  • S. Lawrie
  • Psychology, Medicine
    Therapeutic advances in psychopharmacology
  • 2018
The case against antipsychotics is not proven and the jury is out on any significance of putative antipsychotic-induced brain changes, as the balance of probabilities is that antippsychotic drugs do not cause adverse structural brain changes in schizophrenia.

Impact of cognitive performance on the reproducibility of fMRI activation in schizophrenia.

The findings suggest that the greater variability in activation in patients with schizophrenia compared with controls concerns high-level areas and is mainly attributable to deficient task performance, which means cognitive performance must be carefully controlled when longitudinal fMRI studies are undertaken.



Functional brain imaging and aging in schizophrenia

Review of functional magnetic resonance imaging in schizophrenia

Defining the course of brain structural change and plasticity in schizophrenia

  • L. DeLisi
  • Psychology, Medicine
    Psychiatry Research: Neuroimaging
  • 1999

Regional cerebral blood flow changes associated with risperidone treatment in elderly schizophrenia patients: a pilot study.

It is suggested that the improvement in psychotic symptoms after risperidone is associated with a decrease in frontal and temporal activity and a reduction in 99mTc-HMPAO percentage uptake in the entire cortical area in the slice and agree with data from younger populations.

fMRI Applications in Schizophrenia Research

fMRI has unique potential in the study of psychiatric patients, particularly in characterizing individual variations and changes over time. We have performed four studies of patients with

Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia.

This study provides direct evidence for significantly enhanced frontal function in schizophrenic patients after substitution of risperidone for typical antipsychotic drugs, and it indicates the potential value of functional MRI as a tool for longitudinal assessment of psychopharmacological effects on cerebral physiology.

Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task

The findings suggest that olanzapine has a stronger differential effect on neural activity in prefrontal cortex and thalamus than in motor structures, which may indicate repetition effects rather than drug effects.

Insights and treatment options for psychiatric disorders guided by functional MRI.

  • T. Sharma
  • Psychology, Medicine
    The Journal of clinical investigation
  • 2003
Attempts by researchers to understand the pathophysiology and the mechanism of drug action using functional magnetic resonance imaging (fMRI), a technique that has the obvious advantages of minimal invasiveness, no radioactivity, widespread availability, and virtually unlimited study repetitions are dealt with.

Augmenting Atypical Antipsychotics with a Cognitive Enhancer (Donepezil) Improves Regional Brain Activity in Schizophrenia Patients: A Pilot Double-blind Placebo Controlled BOLD fMRI Study

The cingulate’s role in modulating cognition and neuronal connectivity in schizophrenia is supported, with results suggesting that addition of a cognitive enhancing medication to current antipsychotic therapy might improve functionality of networks necessary in working memory and internal concept generation.

Cerebral metabolism and risperidone treatment in schizophrenia