Corpus ID: 46098718

Review of glucosamine-containing oral joint supplements: are they effective in the horse?

  title={Review of glucosamine-containing oral joint supplements: are they effective in the horse?},
  author={Stacey L. Oke and Jeffrey Scott Weese},
While glucosamine supplementation is very common and a multitude of commercial products are available, there is currently limited information available to assist the equine practitioner in deciding when and how to use these products. Low bioavailability of orally administered glucosamine, poor product quality, low recommended doses, and a lack of scientific evidence showing efficacy of popular oral joint supplements are major concerns. Authors’ addresses: Rolling Thunder Veterinary Services… Expand
4 Citations


Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis.
There is abundant in vitro, in vivo, animal clinical, and human clinical evidence of both their efficacy and safety, and these nutriceuticals deserve a prominent place in the armamentarium of nonsurgical treatment of osteoarthritis. Expand
Active ingredient consistency of commercially available glucosamine sulfate products.
If GLS is used as a therapeutic agent, it is important that the products conform to a standard in their description, and the content is probably best expressed in terms of free base. Expand
Glucosamine: a review of its use in the management of osteoarthritis.
In short-term clinical trials, glucosamine provided effective symptomatic relief for patients with osteoarthritis of the knee and has a tolerability profile similar to that of placebo and is better tolerated than ibuprofen or piroxicam. Expand
Glucosamine for osteoarthritis: magic, hype, or confusion?
People with joint pain, including those with osteoarthritis, are consuming large quantities of glucosamine as a result of a huge volume of recent media coverage on its possible value, and the most appropriate dose and route of administration remain unknown. Expand
Glucosamine for osteoarthritis: part I, review of the clinical evidence.
The National Center for Complementary and Alternative Medicine and the National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS/NCCAM) have funded a multicenter five arm placebo controlled study called The Glucosamine Arthritis Intervention Trial (GAIT). Expand
The use of nutraceuticals for osteoarthritis in horses.
  • T. Trumble
  • Medicine
  • The Veterinary clinics of North America. Equine practice
  • 2005
The main goal for use of nutraceuticals is to use them in OA cases to attempt to lower the dose of other drugs that are more problematic while potentially preventing further degradation (disease or structure modifying). Expand
The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse
If glucosamine (GL) hydrochloride and low molecular weight (LMW) chondroitin sulfate (CS) (TRH122™) are absorbed after oral administration to horses is determined. Expand
The Efficacy of Orally Administered Sulfated Glycosaminoglycan in Chemically Induced Equine Synovitis and Degenerative Joint Disease
It is concluded that commercially available orally administered sulfated GAGs at the dosage and treatment regimen recommended by the manufacturer had no anti-inflammatory or chondroprotective activity compared to untreated controls in the CFA induced equine carpitis model. Expand
Glucosamine Sulfate for Osteoarthritis
There is evidence that glucosamine sulfate may provide pain relief, reduce tenderness, and improve mobility in patients with OA. Expand
Sulfate could mediate the therapeutic effect of glucosamine sulfate.
This hypothesis is clinically relevant because it predicts that nonsulfate salts of glucosamine will be ineffective and that renal function, diet, and concurrent acetaminophen therapy could confound clinical trials of this therapy. Expand