Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.

@article{Nashan2012ReviewOC,
  title={Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.},
  author={Bjorn A P Nashan and Robert S. Gaston and Vincent Emery and Marcus D. S{\"a}emann and Nicolas J Mueller and Lionel Couzi and Jacques Dantal and Fuad S. Shihab and Shamkant P. Mulgaonkar and Yu Seun Kim and Daniel C. Brennan},
  journal={Transplantation},
  year={2012},
  volume={93 11},
  pages={1075-85}
}
Cytomegalovirus (CMV) infection and disease are major complications in the renal transplant recipient. The occurrence of CMV is associated with acute rejection, allograft dysfunction, significant end-organ disease, and mortality. Several clinical studies have indicated that the use of certain immunosuppressive drugs can delay the reconstitution of CMV-specific cell-mediated immune responses, thereby leading to uncontrolled CMV replication. Accumulating evidence indicates, however, that the use… CONTINUE READING
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