Review of computer simulations of isotope effects on biochemical reactions: From the Bigeleisen equation to Feynman's path integral.

@article{Wong2015ReviewOC,
  title={Review of computer simulations of isotope effects on biochemical reactions: From the Bigeleisen equation to Feynman's path integral.},
  author={K. Y. Wong and Yuqing Xu and L. Xu},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1854 11},
  pages={
          1782-94
        }
}
  • K. Y. Wong, Yuqing Xu, L. Xu
  • Published 2015
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • Enzymatic reactions are integral components in many biological functions and malfunctions. The iconic structure of each reaction path for elucidating the reaction mechanism in details is the molecular structure of the rate-limiting transition state (RLTS). But RLTS is very hard to get caught or to get visualized by experimentalists. In spite of the lack of explicit molecular structure of the RLTS in experiment, we still can trace out the RLTS unique "fingerprints" by measuring the isotope… CONTINUE READING
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