Review of combination therapies for neovascular age-related macular degeneration.

  title={Review of combination therapies for neovascular age-related macular degeneration.},
  author={Steven M. Couch and Sophie J. Bakri},
  journal={Seminars in ophthalmology},
  volume={26 3},
While angiogenesis is one of the factors associated with the development of CNV due to age-related macular degeneration (AMD), inflammation and oxidative stress also appear to play a role. Treatment of CNV with intravitreal anti-vascular endothelial growth factor monotherapy is currently the standard of care. However, not all patients respond to monotherapy, and combination therapy may target the CNV through multiple mechanisms, thus reducing treatment frequency or improving visual outcome… CONTINUE READING
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