Review of clinical experience with estradiol in combined oral contraceptives.

@article{Fruzzetti2010ReviewOC,
  title={Review of clinical experience with estradiol in combined oral contraceptives.},
  author={F. Fruzzetti and J. Bitzer},
  journal={Contraception},
  year={2010},
  volume={81 1},
  pages={
          8-15
        }
}
Previous attempts to replace ethinylestradiol (EE) with 17beta-estradiol (E2) in combined oral contraceptives (COCs) have proved unsatisfactory in terms of bleeding outcomes. A review of previous studies of E2-based COCs has shown that, despite good ovulation inhibition, bleeding irregularities affected up to 100% of women, often resulting in high rates of discontinuation (up to 42%). Suggested reasons for the bleeding irregularities observed with these predominantly monophasic estradiol… Expand
Metabolic impact of combined hormonal contraceptives containing estradiol
Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen
  • L. Shulman
  • Medicine
  • Journal of Family Planning and Reproductive Health Care
  • 2013
Estradiol in non-oral hormonal contraception: a “long and winding road”
Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?
  • G. Grandi, F. Facchinetti, J. Bitzer
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2017
Novel oral contraceptive for heavy menstrual bleeding: estradiol valerate and dienogest
Nomegestrol Acetate/Estradiol
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Clinical findings with the oral contraceptive combination ethinylestradiol/dienogest in the Czech Republic.
Clinical findings with the oral contraceptive combination ethinylestradiol/dienogest in Poland.
Efficacy and tolerability of a monophasic oral contraceptive containing ethinylestradiol and drospirenone
  • J. Huber, J. Foidart, +5 authors R. Heithecker
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2000
Oral contraceptive containing natural estradiol for premenopausal women.
Ovulation inhibition with a combined oral contraceptive containing 1 mg micronized 17 beta-estradiol.
Approaches to the replacement of ethinylestradiol by natural 17beta-estradiol in combined oral contraceptives.
  • H. Hoffmann, C. Moore, +4 authors M. Oettel
  • Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1998
...
1
2
3
4
...