Review of carbamazepine-induced hyponatremia

@article{Gandelman1994ReviewOC,
  title={Review of carbamazepine-induced hyponatremia},
  author={Mitchell S. Gandelman},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1994},
  volume={18},
  pages={211-233}
}
  • M. Gandelman
  • Published 1994
  • Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
1. Carbamazepine (CBZ), a commonly prescribed medication in psychiatry and neurology, produces deleterious side effects with an incidence rate ranging from 33-50%; although most of these side effects are mild, transient, and reversible. CBZ-induced hyponatremia is a moderately well described side effect and may be responsible for some of the more highly reported signs and symptoms associated with CBZ adverse effects. 2. Data from case reports and clinical studies are examined to ascertain the… Expand
Incidence and Predictive Factors of Hyponatremia in Acute Carbamazepine Exposure
Introduction: Hyponatremia, an electrolyte abnormality reported during long-term treatment with carbamazepine (CBZ), is increasingly observed in acute poisoning. Its incidence and predictive factorsExpand
[Carbamazepine-induced hyponatremia].
TLDR
The case of a 59-year-old man with arterial hypertension, already treated with hydrochlorothiazide, who presented with hyponatremia after starting administration of carbamazepine is described and routine assessment of blood electrolytes is reasonable. Expand
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A case of a 60-year-old female patient presenting in emergency department with history of carbamazepine-induced hyponatremia is presented, diagnosed as a case of syndrome of inappropriate ADH and was treated accordingly. Expand
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Psychotropic medication-induced hyponatraemia is an uncommon but important clinical problem with potential serious consequences if not recognised and treated early. Several risk factors have beenExpand
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Several factors should be considered for a safer use of CBZ, such as monotherapy prescription when possible, an adequate dose titration, knowledge of previous ADRs in the patient, and routine monitoring ofCBZ plasma concentrations in symptomatic patients. Expand
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Epidemiology, pathophysiology and putative genetic basis of carbamazepine‐ and oxcarbazepine‐induced hyponatremia
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The use of carbamazepine and oxcarbazepine as first‐line antiepileptic drugs in the treatment of focal epilepsy is limited by hyponatremia, a known adverse effect that can lead to symptoms ranging from unsteadiness and mild confusion to seizures and coma. Expand
Carbamazepine- or Oxcarbazepine-Induced Hyponatraemia or Leucopenia, or Both, in Residents with a Developmental Disability.
TLDR
A negative correlation between sodium and serum carbamazepine levels was found and a population at risk of hyponatraemic effect was defined. Expand
Hyponatremia from oxcarbazepine and carbamazepine
TLDR
Examination of sodium concentrations from patients with epilepsy using cross-section and follow-up studies found that advanced age was a risk factor for hyponatremia, once present, persisted in both groups. Expand
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  • N. Himmerkus, B. Sievers, M. Bleich
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2012
TLDR
Its enhanced influence on urinary flow and natriuresis in the presence of satavaptan suggests additional renal targets for CBZ, independent of vasopressin signalling. Expand
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TLDR
In a study of the incidence of side effects in 220 children below the age of 16 years who were receiving carbamazepine, drowsiness, loss of coordination, and vertigo were the most commonly observed side effects and were almost always transient and dose related. Expand
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TLDR
There was a significant difference in serum sodium level between patients receiving carbamazepine alone and those also receiving lithium, and the protection against hyponatremia provided by the carbamazEPine-lithium combination occurred despite lithium's tendency to increase polyuria. Expand
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TLDR
It is concluded that the antidiuretic effect of carbamazepine is not the result of releasing endogenous antidiuresis hormone or of prolonging its half-life. Expand
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  • M. B. Lahr
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1985
TLDR
The risk of hyponatremia increased with age and carbamazepine serum level (subjects >30 years old had three‐and‐a‐half times the prevalence as those with lower levels). Expand
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TLDR
It appears that carbamazepine is worthwhile in patients with some aggression and interpersonal difficulties who are refractory to neuroleptics alone and who exhibit instability and agitation. Expand
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TLDR
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TLDR
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TLDR
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TLDR
It is suggested that caution be used in prescribing carbamazepine to patients with low or borderline low sodium values, as three of these patients developed frank symptoms of hyponatremia within 1-3 months of the start of therapy. Expand
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TLDR
Two patients, one with trigeminal neuralgia, the other with epilepsy, who developed carbamazepine-induced abnormal water retention are described, which might provide a link between these two conditions. Expand
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