Review of bemiparin sodium – a new second-generation low molecular weight heparinand its applications in venous thromboembolism

@article{Plans2003ReviewOB,
  title={Review of bemiparin sodium – a new second-generation low molecular weight heparinand its applications in venous thromboembolism},
  author={Andr{\'e} Plan{\`e}s},
  journal={Expert Opinion on Pharmacotherapy},
  year={2003},
  volume={4},
  pages={1551 - 1561}
}
  • A. Planès
  • Published 1 September 2003
  • Medicine
  • Expert Opinion on Pharmacotherapy
Bemiparin sodium (Hibor®, Ivor®, Zivor®, Badyket®, Laboratorios Farmaceuticos Rovi SA) is a new second-generation low molecular weight heparin (LMWH). Bemiparin has the lowest mean molecular weight (3600 Da), the longest half-life (5.3 h) and the largest antifactor Xa:antifactor IIa ratio (8:1) of all LMWHs. Bemiparin promotes a greater release of tissue factor pathway inhibitor than unfractionated heparin (UFH) or dalteparin. These properties could result in a more favourable efficacy:safety… 
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Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism
TLDR
Results from multicenter pharmacoeconomic studies in the Spanish Health Care System indicate that bemiparin is more cost effective than enoxaparin for the prevention of VTE in total knee replacement and may be a safe, cost-saving alternative to unfractionated heparin in the short-term treatment of Vte, and a safe cost-neutral alternative to oral anticoagulant therapy in long- term treatment.
New challenges for a second-generation low-molecular-weight heparin: focus on bemiparin
TLDR
Results from ongoing trials could be critical to establish the potential of bemiparin in oncological patients since international guidelines recommend LMWHs for initial and continuous anticoagulant treatment in cancer patients with VTE, as well as for its prevention.
Bemiparin: pharmacological profile.
TLDR
Bemiparin increased the release and activity of tissue factor pathway inhibitor (TFPI) from endothelial cells under both static conditions and arterial sheer stress and has good antithrombotic activity and a better pharmacological profile than unfractionated heparin.
Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis
TLDR
Bemiparin plus OAC or long-term bemiparin for 3 months may be dominant strategies over UFHplus OAC in the treatment of DVT from the Spanish National Health System perspective, offering better outcomes and cost savings.
Thromboprophylaxis with the Low-Molecular-Weight Heparin Bemiparin Sodium in Elderly Medical Patients in Usual Clinical Practice
TLDR
Bemiparin sodium thromboprophylaxis for 4–5 weeks was associated with a low incidence of VTE and a low rate of bleeding and other complications in non-surgical elderly patients at risk of V TE, treated either in GCs or in HHUs, in standard clinical practice.
Pharmacoeconomic Analysis of Bemiparin and Enoxaparin as Prophylaxis for Venous Thromboembolism in Total Knee Replacement Surgery
TLDR
The model suggests that bemiparin may be more cost effective than enoxaparin for thromboprophylaxis in total knee replacement surgery in the Spanish healthcare setting.
Low-Molecular-Weight Heparins: Before or After Surgery? New Concepts and Evidence
TLDR
Of particular interest were the issues debated during the Sigma Tau/ROVI Satellite Symposium, which focused on the optimal timing strategy for initiating thromboprophylaxis in patients undergoing orthopaedic surgery.
Bemiparin Versus Unfractionated Heparin as Bridging Therapy in the Perioperative Management of Patients on Vitamin K Antagonists: The BERTA Study
TLDR
Despite its small size, the BERTA study is the first randomised, double-blind clinical trial comparing UFH with a fixed high-risk thromboprophylactic dose of an LMWH as bridging therapy and suggests that bemiparin is at least as safe as UFH as bridges therapy.
Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice.
Cost–effectiveness of bemiparin in the prevention and treatment of venous thromboembolism
TLDR
Bemiparin may be a safer and cost-neutral alternative to oral anticoagulants for long-term treatment (secondary prophylaxis) of venous thromboembolism.
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