Review of aldosterone- and angiotensin II-induced target organ damage and prevention.

  title={Review of aldosterone- and angiotensin II-induced target organ damage and prevention.},
  author={Allan D. Struthers and Thomas M. MacDonald},
  journal={Cardiovascular research},
  volume={61 4},
Aldosterone is well recognized as a cause of sodium reabsorption, water retention, and potassium and magnesium loss; however, it also produces a variety of other actions that lead to progressive target organ damage in the heart, vasculature, and kidneys. Aldosterone interacts with mineralocorticoid receptors to promote endothelial dysfunction, facilitate thrombosis, reduce vascular compliance, impair baroreceptor function, and cause myocardial and vascular fibrosis. Although angiotensin II has… CONTINUE READING
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