Review of Tolvaptan’s Pharmacokinetic and Pharmacodynamic Properties and Drug Interactions

@inproceedings{Bhatt2014ReviewOT,
  title={Review of Tolvaptan’s Pharmacokinetic and Pharmacodynamic Properties and Drug Interactions},
  author={Purav R. Bhatt and Elizabeth B. McNeely and Tess E. Lin and Kirkwood F. Adams and J. Herbert Patterson and Lewis S. Blevins},
  booktitle={Journal of clinical medicine},
  year={2014}
}
Tolvaptan is an arginine vasopressin (AVP) antagonist that acts to increase excretion of free water (aquaresis) in patients without introducing electrolyte abnormalities or worsening renal function. It works via blockade of vasopressin-2 receptors at the renal collecting duct. Since the approval of tolvaptan for the treatment of hypervolemic and euvolemic hyponatremia in 2009, new studies have been reported to better characterize its pharmacokinetic and pharmacodynamic profile of tolvaptan… CONTINUE READING
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