Review of Progressive Multifocal Leukoencephalopathy and Natalizumab

@article{Aksamit2006ReviewOP,
  title={Review of Progressive Multifocal Leukoencephalopathy and Natalizumab},
  author={Allen Jr. Aksamit},
  journal={The Neurologist},
  year={2006},
  volume={12},
  pages={293-298}
}
  • A. Aksamit
  • Published 1 November 2006
  • Medicine
  • The Neurologist
Background:Progressive multifocal leukoencephalopathy (PML), a destructive demyelinating infection which lytically infects oligodendrocytes, has occurred in patients treated with natalizumab. Magnetic resonance imaging (MRI) scan imaging of the brain gives clues to diagnosis but is nonspecific in distinguishing multiple sclerosis from PML. Spinal fluid detection of JC virus is specific but incompletely sensitive. Associated immunosuppression is typically of the cell-mediated type but can be… 
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