Review of Cannabinoids and their Antiemetic Effectiveness

@article{Vincent2012ReviewOC,
  title={Review of Cannabinoids and their Antiemetic Effectiveness},
  author={Beverly J. Vincent and Debra McQuiston and Lawrence H. Einhorn and C Nagy and Mary Jacqueline Brames},
  journal={Drugs},
  year={2012},
  volume={25},
  pages={52-62}
}
SummaryMarijuana has been used for over 2 centuries. Its major psychoactive constituent, delta-9-tetrahydrocannabinol (THC) was isolated in 1964 and first used to control nausea and vomiting during chemotherapy in the 1970s.THC has cardiovascular, pulmonary and endocrinological effects as well as actions on the central nervous system. Alterations in mood, memory, motor coordination, cognitive ability, sensorium, spatial- and self-perception are commonly experienced. The precise antiemetic… 
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References

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TLDR
THC appears to be an effective antiemetic in cancer patients undergoing chemotherapy and has been found consistently more effective than placebo and at least as effective as prochlorperazine.
Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.
TLDR
Although THC may have a role in preventing nausea and vomiting associated with cancer chemotherapy, this role must be more clearly defined before THC can be recommended for general use.
Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.
TLDR
Oral tetrahydrocannabinol has antiemetic properties and is significantly better than a placebo in reducting vomiting caused by chemotherapeutic agents.
Suppression of Cancer Chemotherapy-Induced Vomiting in the Cat by Nabilone, a Synthetic Cannabinoid 1
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TLDR
It is suggested that the emetic suppressant action of nabilone is effected in the fbrebrain in association with its psychotropic influence to cause an inhibition of the vomiting control mechanism in the medulla oblongata through descending connections.
Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.
TLDR
Tetrahydrocannabinol appears to offer significant control of nausea in most patients and exceeding by far that provided by prochlorperazine, as well as more efficacious for cyclophosphamide, fluorouracil, and doxorubicin hydrochloride and the nitrosureas.
Nabilone: a potent antiemetic cannabinol with minimal euphoria.
Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in
Delata-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation.
TLDR
Delta-9-tetrahydrocannabinol appears to have significant antiemetic properties when compared with placebo in patients receiving high-dose methotrexate in patients with osteogenic sarcoma.
METABOLISM AND DISPOSITION OF TETRAHYDROCANNABINOLS IN NÄIVE SUBJECTS AND CHRONIC MARIJUANA USERS
TLDR
It is therefore possible that Cannabis could be reinstituted in the physicians' armamentarium and of special importance to study the disposition and metabolism of A9-THC in man.
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TLDR
Delta-9-tetrahydrocannabinol (THC) is an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective.
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TLDR
It is concluded that intramuscular levonantradol is an effective antiemetic at doses as low as 0.5 mg, and the most commonly reported side effects were somnolence and dry mouth.
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