Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome

  title={Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome},
  author={Ahmed Helmy},
  journal={Alimentary Pharmacology \& Therapeutics},
  • A. Helmy
  • Published 1 January 2006
  • Medicine, Biology
  • Alimentary Pharmacology & Therapeutics
Hepatic sinusoidal obstruction syndrome is frequently linked to high‐dose chemotherapy/total‐body irradiation in recipients of haematopoietic stem cell transplantation, long‐term use of azathioprine after organ transplantation and other chemotherapeutic agents. The incidence of hepatic sinusoidal obstruction syndrome varies from 0% to 70%, and is decreasing. 
Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome
The drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non‐tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy.
Sinusoidal obstruction syndrome
Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites
It is hypothesized that PEG‐asparaginase, combined with other drugs, may trigger SOS during 6‐thioguanine‐free maintenance therapy.
Nutrition challenges in a patient with sinusoidal obstructive syndrome following an allogeneic stem cell transplant: a case study.
  • K. Ringo, Louise Chen
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2012
The nutrition implications and interventions in a patient who developed SOS following an allogeneic matched unrelated donor (Allo/MUD) HSCT are reviewed in the case report.
Hepatic Sinusoidal Obstruction Syndrome without Preceding Medical Events
Hepatic SOS needs to be included in the differential diagnosis of progressive ascites in patients without an apparent history of malignancy or transplantation, according to autopsy of a case of rapidly progressive, uncontrollable severe ascites.
Interventions for treatment of hepatic veno‐occlusive disease in patients undergoing hematopoietic stem cell transplantation
The author made no progress with the review within the last 12 months and the manuscript was withdrawn from publication.
Hepatic sinusoidal obstruction syndrome in patients undergoing hematopoietic stem cell transplant.
A comprehensive review of hepatic sinusoidal obstruction syndrome in patients receiving a hematopoietic stem cell transplant is provided and the implications for nursing care are described.
Hepatic Sinusoidal Obstruction Syndrome in the Era of Defibrotide
Defibrotide, a novel agent in SOS, has been shown to improve the clinical outcome and survival in patients with severe VOD and should be considered for DF prophylaxis.
Sinusoidal Obstruction Syndrome during oxaliplatin based chemotherapy treatment.
A clinical course of venoocclusive disease, which developed in third stage colonic cancer, treated with capecitabine and oxaliplatin as adjuvant treatment is presented.
Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine, Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment with Defibrotide
A 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide was treated successfully with defibrotide without sequelae to the liver.


Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment
The pathogenesis and clinical features of Hepatic veno-occlusive disease are outlined, with an emphasis on endothelial cell injury and risk factors.
Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation.
A comprehensive account of the pathophysiology of this disease as it is understood today, risk factors for its development, and the current state of knowledge regarding preventive and therapeutic options are provided.
Role of endothelial cell injury in the spectrum of azathioprine-induced liver disease after renal transplant: light microscopy and ultrastructural observations.
It was found that the azathioprine-induced complex of liver diseases produces a spectrum of pathological changes that include veno-occlusive disease, peliosis hepatis, perisinusoidal fibrosis, and nodular regenerative hyperplasia.
The syndrome of hepatic veno-occlusive disease after marrow transplantation.
Therapeutic drug monitoring of busulfan and pharmacokinetic dose adjustments appear to be useful in reducing the incidence of VOD in patients receiving this agent and treatment with recombinant tissue plasminogen activator has promise.
Hepatic outflow obstruction and liver failure due to leukemic cell infiltration in chronic lymphocytic leukemia.
This is apparently the first report of a CLL patient with HVOD and liver failure, attributable to liver infiltration by leukemic cells, according to reports of advanced progressive CLL.
Favourable outcome of hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine, treated by portacaval shunt. Report of a case and review of the literature.
Veno-occlusive disease developed in a 45-year-old white male 2 years after cadaveric kidney transplantation while receiving combined immunosuppressive therapy with prednisone and azathioprine, and required surgical treatment by portacaval shunt.
[Veno-occlusive disease after liver transplantation. Association of acute cellular rejection and toxicity of azathioprine].
A new case in a patient who developed veno-occlusive disease of the liver 3 weeks after liver transplantation, which may have been enhanced by a previous episode of severe, acute rejection prevailing in the hepatic veins.
Acute Sinusoidal Obstruction Syndrome After 6-Thioguanine Therapy for Crohn’s Disease
A patient who developed acute sinusoidal obstruction syndrome after 14 months of successful thioguanine treatment is reported, the first report of such a complication in an adult treated with 6-TG for active Crohn’s disease.
Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease).
This review encompasses historical perspectives, clinical manifestations of Sinusoidal obstruction syndrome in the setting of hematopoietic cell transplantation, histologic features of centrilobular injury, and a discussion of the pathophysiology of sinusoidal injury, based on both animal and clinical investigations.