Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome

@article{Helmy2006ReviewAU,
  title={Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome},
  author={Ahmed Helmy},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2006},
  volume={23}
}
  • A. Helmy
  • Published 1 January 2006
  • Medicine, Biology
  • Alimentary Pharmacology & Therapeutics
Hepatic sinusoidal obstruction syndrome is frequently linked to high‐dose chemotherapy/total‐body irradiation in recipients of haematopoietic stem cell transplantation, long‐term use of azathioprine after organ transplantation and other chemotherapeutic agents. The incidence of hepatic sinusoidal obstruction syndrome varies from 0% to 70%, and is decreasing. 
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TLDR
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TLDR
Defibrotide, a novel agent in SOS, has been shown to improve the clinical outcome and survival in patients with severe VOD and should be considered for DF prophylaxis.
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A 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide was treated successfully with defibrotide without sequelae to the liver.
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