Review article: the role of inflammation in the pathogenesis of gastric cancer

@article{Ernst1999ReviewAT,
  title={Review article: the role of inflammation in the pathogenesis of gastric cancer},
  author={P. Ernst},
  journal={Alimentary Pharmacology & Therapeutics},
  year={1999},
  volume={13}
}
  • P. Ernst
  • Published 1999
  • Medicine
  • Alimentary Pharmacology & Therapeutics
  • Helicobacter pylori induces infiltration of the gastric mucosa by polymorphonuclear cells and macrophages, as well as T and B lymphocytes. Paradoxically, this robust immune/inflammatory response cannot clear the infection, and thus leaves the host prone to complications resulting from chronic inflammation. One adverse consequence of this inflammatory response may be gastric cancer, as inflammation has been implicated in the development of intestinal metaplasia and mutations in oncogenes that… CONTINUE READING
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