Review article: the role of inflammation in the pathogenesis of gastric cancer

@article{Ernst1999ReviewAT,
  title={Review article: the role of inflammation in the pathogenesis of gastric cancer},
  author={Peter B. Ernst},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={1999},
  volume={13}
}
  • P. Ernst
  • Published 1999
  • Medicine
  • Alimentary Pharmacology & Therapeutics
Helicobacter pylori induces infiltration of the gastric mucosa by polymorphonuclear cells and macrophages, as well as T and B lymphocytes. Paradoxically, this robust immune/inflammatory response cannot clear the infection, and thus leaves the host prone to complications resulting from chronic inflammation. One adverse consequence of this inflammatory response may be gastric cancer, as inflammation has been implicated in the development of intestinal metaplasia and mutations in oncogenes that… Expand
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AN OVERVIEW OF HELICOBACTER PYLORI INFECTIONS WITH SPECIAL REFERENCE TO PATHOGENESIS AND MECHANISM OF COLONIZATION
Helicobacter pylori is the major causative agent of gastrointestinal diseases. The bacterial pathogen, H. pylori has co-evolved with humans and colonize about 50% of the human population, whichExpand
Influence of cytokine gene polymorphisms and of the Helicobacter pylori outer membrane protein Hp0638 on bacterial pathogenesis
TLDR
It is shown that cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation and the long-term development of precancerous lesions in H. pylori infection. Expand
Gastric angiogenesis and Helicobacter pylori infection.
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  • Medicine
  • Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
  • 2006
TLDR
While the angiogenic process becomes inhibited in infected patients with peptic ulcer, it remains seemingly active in those with gastritis or gastric cancer, in support of the notion suggested by various studies that peptic Ulcer and Gastric cancer are mutually excluding conditions. Expand
Helicobacter pylori as a promoter of accelerated regeneration, pathological differentiation and transformation of normal gastric mucosa into cancerous type.
TLDR
The study confirmed Helicobaster pylori responsibility for inflammatory events in gastric mucosa in patients with gastric carcinoma, andlight and mild epithelial dysplasia with chronic atrophic gastritis grade I and II coupled with intestinal metaplasia may be considered an indicator for early detection of carcinoma. Expand
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