Review article: the pathophysiology and medical management of diverticulosis and diverticular disease of the colon

@article{Tursi2015ReviewAT,
  title={Review article: the pathophysiology and medical management of diverticulosis and diverticular disease of the colon},
  author={Antonio Tursi and Alfredo Papa and Silvio Danese},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2015},
  volume={42}
}
The incidence of diverticulosis and diverticular disease of the colon, including diverticulitis, is increasing worldwide, and becoming a significant burden on national health systems. Treatment of patients with diverticulosis and DD is generally based on high‐fibre diet and antibiotics, respectively. However, new pathophysiological knowledge suggests that further treatment may be useful. 
article : the pathophysiology and medical management of diverticulosis and diverticular disease of the colon
Background The incidence of diverticulosis and diverticular disease of the colon, including diverticulitis, is increasing worldwide, and becoming a significant burden on national health systems.Expand
Diverticulosis today.
TLDR
Focus is now being drawn on identifying a new endoscopic classification of the disease to evaluate the correct therapeutic approach by testing various treatments, and Fiber, non-absorbable antibiotics and probiotics seem to be effective in treating symptomatic and uncomplicated patients. Expand
Diverticulosis, Diverticulitis, and Diverticular Bleeding.
TLDR
Diverticulosis presents as acute lower abdominal pain, and initial management traditionally includes antibiotics, with surgery reserved for complicated disease, although newer evidence questions the optimal role and timing of both interventions. Expand
Fiber and Diverticular Disease
TLDR
Diverticular disease is among the most clinically and economically significant gastroenterological conditions in people > 65 years of age, and in some individuals there may be eventual complications such as severe bouts of diverticulitis or bleeding that may lead to sepsis and death. Expand
Management of symptomatic uncomplicated diverticular colon disease: A systematic review of diagnosis and treatment
TLDR
The objective of this systematic review is to clarify the existing scientific evidence and analyse the use of the different diagnostic and therapeutic options for SUDCD, comparing their advantages and disadvantages, to suggest a diagnostic-therapeutic algorithm for this pathology and propose new research questions. Expand
Cyclic rifaximin and soluble dietary fiber therapy for symptomatic diverticular disease: effective prevention of complications
The article discusses the current issues of managing patients with colonic diverticular disease. The prevalence of pathology is steadily increasing, which is due to the more frequent diagnosis of theExpand
Current Management of Patients With Diverticulosis and Diverticular Disease: A Survey From the 2nd International Symposium on Diverticular Disease
TLDR
Current management of DD is similar between different medical specialities, generally in line with current literature, and no differences were found among gastroenterologists, surgeons, and general practitioners in managing this disease. Expand
Development and usefulness of the new endoscopic classification: DICA
TLDR
The aim of this article is to focus on the process of the development and the validation of the classification by the pool of gastroenterology experts, and its usefulness during the clinical practice. Expand
How to Differentiate Segmental Colitis Associated With Diverticulosis and Inflammatory Bowel Diseases.
TLDR
Compared with inflammatory bowel disease, SCAD seems to have a more benign outcome, with low rate of complications, and recent data have hypothesized that SCAD may be an independent clinical entity within theinflammatory bowel disease set of diseases. Expand
Paradigm shift: the Copernican revolution in diverticular disease
TLDR
A comprehensive and critical reappraisal of the proposed modifications of the endoscopic classification and therapeutic approaches to the management of DD patients is performed, aiming to discriminate between certainties and doubts on this issue. Expand
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References

SHOWING 1-10 OF 151 REFERENCES
Review article: the current and evolving treatment of colonic diverticular disease
TLDR
Diverticular disease can be associated with numerous debilitating abdominal and gastrointestinal symptoms (including pain, bloating, nausea, constipation and diarrhoea). Expand
Diverticular Disease and Diverticulitis
TLDR
The epidemiology, pathophysiology, clinical presentation, and management of the spectrum of diverticular disease, including mention of recent advances in the treatment of chronic diversionicular disease with aminosalicyclates and probiotics are discussed. Expand
Review article: the pathogenesis and management of acute colonic diverticulitis
Acute diverticulitis, defined as acute inflammation associated with a colonic diverticulum, is a common emergency presentation managed by both surgeons and physicians. There have been advances inExpand
New physiopathological and therapeutic approaches to diverticular disease: an update
  • A. Tursi
  • Medicine
  • Expert opinion on pharmacotherapy
  • 2014
TLDR
Although absorbable antibiotics and 5-aminosalycilic acid seem to be effective in treating SUDD, their role in preventing diverticulitis recurrence is still under debate andAntibiotic use in managing acute diverticsulitis is at least questionable, and use of probiotics seems to be promising but need further robust studies to confirm the preliminary results. Expand
Mild colonic diverticulitis can be treated without antibiotics. a case–control study
TLDR
The aim of this study is to evaluate the need for antibiotics in mild colonic diverticulitis and to determine the beneficiary effect of antibiotics. Expand
The changing trend of diverticular disease in a developing Nation
TLDR
Whether the prevalence, site and distribution of diverticular disease in the Oriental population has changed over the past two decades has been determined. Expand
Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation
  • D. Humes, J. Simpson, +6 authors R. Spiller
  • Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2012
TLDR
The aim was to assess visceral sensitivity in patients with diverticular disease and its association with markers of previous inflammation and neuropeptides. Expand
Advances in the management of colonic diverticulitis
  • A. Tursi
  • Medicine
  • Canadian Medical Association Journal
  • 2012
TLDR
Diverticular disease is characterized by the presence of sac-like protrusions that form in the colon wall when the mucosa and submucosa herniate through defects in the muscle layer of the wall. Expand
Diverticulitis: when and how to operate?
  • H. Aydin, F. Remzi
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2004
TLDR
The surgical treatment of diverticulitis is reviewed with regard to indications, timeliness of operative intervention, operative options and techniques, and special circumstances. Expand
Italian consensus conference for colonic diverticulosis and diverticular disease
The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. TopicsExpand
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