Review article: the modern management of hepatic encephalopathy

@article{Bajaj2010ReviewAT,
  title={Review article: the modern management of hepatic encephalopathy},
  author={Jasmohan Singh Bajaj},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2010},
  volume={31}
}
  • J. Bajaj
  • Published 2010
  • Medicine
  • Alimentary Pharmacology & Therapeutics
Aliment Pharmacol Ther 31, 537–547 

Paper Mentions

Systematic review with meta‐analysis: the effects of rifaximin in hepatic encephalopathy
TLDR
Rifaximin is recommended for prevention of hepatic encephalopathy (HE) and its effects on overt and minimal HE are debated. Expand
Prolonged remission from hepatic encephalopathy with rifaximin: results of a placebo crossover analysis
Rifaximin therapy reduced risk of hepatic encephalopathy (HE) recurrence and HE‐related hospitalisations during a 6‐month, randomised, placebo‐controlled trial (RCT) and a 24‐month open‐labelExpand
Rifaximin maintained remission from hepatic encephalopathy longer than placebo in patients with cirrhosis
Source Citation Bass NM, Mullen KD, Sanyal A, et al. Rifaximin treatment in hepatic encephalopathy. N Engl J Med. 2010;362:1071-81. 20335583
HEPATIC ENCEPHALOPATHY : A PARADIGM SHIFT
1. Clinic for Gastroenterology, Hepatology and Infectious Diseases Liver Center Düsseldorf, Heinrich Heine University Düsseldorf, Germany 2. Departments of Hepatology and Clinical Epidemiology,Expand
Improvement in survival associated with embolisation of spontaneous portosystemic shunt in patients with recurrent hepatic encephalopathy
Spontaneous portosystemic shunt (SPSS) is a frequent cause of recurrent hepatic encephalopathy (HE) in patients with cirrhosis.
Primary prophylaxis of overt hepatic encephalopathy in patients with cirrhosis: An open labeled randomized controlled trial of lactulose versus no lactulose
TLDR
There is no study on the prevention of overt HE using lactulose in patients who never had HE earlier, so this work is aimed at identifying patients who need to be screened for HE. Expand
Diagnosis and Management of Hepatic Encephalopathy
  • J. Bajaj
  • Springer International Publishing
  • 2018
The pathogenesis of this condition is not well defined. Accumulation of ammonia from the gut and other sources due to impaired hepatic clearance or portosystemic shunting can lead to accumulation ofExpand
Management of Hepatic Encephalopathy by Traditional Chinese Medicine
  • Chun Yao, N. Tang, +7 authors W. Jia
  • Medicine
  • Evidence-based complementary and alternative medicine : eCAM
  • 2012
TLDR
The diagnostic and therapeutic approaches used for HE in modern medicine and traditional Chinese medicine are summarized and future perspective in HE therapies from the viewpoint of holistic and personalized Chinese medicine is provided. Expand
Oral l‐ornithine‐l‐aspartate in minimal hepatic encephalopathy: A randomized, double‐blind, placebo‐controlled trial
TLDR
Evaluate efficacy/safety of oral l‐ornithine‐l‐aspartate (LOLA) in controlling minimal hepatic encephalopathy (MHE) and investigate the role of EMT in controlling MHE. Expand
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References

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A scale to assess the severity of hepatic encephalopathy using simple dichotomic items is developed and shown to be effective in both acute and long-term cases. Expand
Review article: the current pharmacological therapies for hepatic encephalopathy
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Effective treatment options for hepatic encephalopathy are limited and current therapeutic approaches are directed at reducing bacterial production of ammonia and enhancing its elimination. Expand
Review article: the burden of hepatic encephalopathy
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Hepatic encephalopathy, a challenging complication of advanced liver disease, occurs in approximately 30–45% of patients with cirrhosis and 10–50% of patients with transjugular intrahepaticExpand
Review: lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics.
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Source Citation Als-Nielsen B, Gluud LL, GLUud C. Nonabsorbable disaccharides for hepatic encephalopathy: Causes and treatments, Cochrane Database Syst Rev. 2004. Expand
Therapeutic studies in hepatic encephalopathy
TLDR
The first section deals with the justification for placebo-controlled trials in hepatic encephalopathy, and the other two sections discuss, in detail, outcome parameters for therapeutic studies in the clinical and research setting, respectively. Expand
Review of the final report of the 1998 Working Party on definition, nomenclature and diagnosis of hepatic encephalopathy
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The heterogeneity and variability of the manifestations of hepatic encephalopathy among patients and in individual patients over time make the condition difficult to diagnose and to categorize withExpand
Efficacy of Lactulose in Cirrhotic Patients with Subclinical Hepatic Encephalopathy
TLDR
It is concluded that lactulose treatment in cirrhotic patients with SHE is effective and the diagnosis of SHE was made by quantitative psychometric tests including the number connection test, figure connection test and FCT, and two performance subtests of Wechsler adult intelligence scale. Expand
Review: Rifaximin is equally or more effective than other antibiotics and lactulose for hepatic encephalopathy
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TLDR
In patients with hepatic encephalopathy, rifaximin is as effective as other antibiotics and may be more effective than nonabsorbable disaccharides and therefore should be used for patients with decompensated cirrhosis. Expand
Rifaximin in the treatment of hepatic encephalopathy
TLDR
The use and efficacy of rifaximin both in acute and long-term management of hepatic encephalopathy is reviewed, including management of the acute episode as well as maintenance of remission in those patients who have previously experienced an episode, in order to improve their quality of life. Expand
Nonabsorbable disaccharides for hepatic encephalopathy.
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It is found that antibiotics appeared to be superior to nonabsorbable disaccharides in improving hepatic encephalopathy, but it is unclear whether this difference in treatment effect is clinically important to patients. Expand
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