Review article: the extra‐skeletal effects of vitamin D in chronic hepatitis C infection

  title={Review article: the extra‐skeletal effects of vitamin D in chronic hepatitis C infection},
  author={Evangelos Cholongitas and Eleni Theocharidou and John Goulis and Emmanuel A. Tsochatzis and Evangelos A. Akriviadis and A. K. Burroughs},
  journal={Alimentary Pharmacology \& Therapeutics},
Recent interest has focused on the extra‐skeletal effects of vitamin D, in particular, in patients with chronic hepatitis C. 
The association between serological and dietary vitamin D levels and hepatitis C‐related liver disease risk differs in African American and white males
Vitamin D may affect the severity of HCV‐related liver disease and the need for vitamin D supplementation in patients with liver disease.
Serum vitamin D level is associated with disease severity and response to ursodeoxycholic acid in primary biliary cirrhosis
Serum vitamin D levels are associated with bone complications in patients with primary biliary cirrhosis (PBC). Increasing evidence suggests a nonskeletal role of vitamin D in various autoimmune and
Vitamin D for your patients with chronic hepatitis C?
25‐Hydroxy vitamin D suppresses hepatitis C virus replication and contributes to rapid virological response of treatment efficacy
This work aimed to clarify whether HCV replication is inhibited by Vit D in HCV replicon cells, and assessed for rapid virological response (RVR) and sustained virology response (SVR) among those patients receiving antiviral therapy.
Recent updates on vitamin D and pediatric gastrointestinal diseases
This article reviews recent publications, regarding vitamin D deficiency and childhood gastrointestinal diseases, and introduces new treatment and prevention guidelines foritamin D deficiency.
Vitamin D in chronic liver disease
Chronic liver disease (CLD) and several related extrahepatic manifestations such as hepatic osteodystrophy are associated with deficiency of vitamin D, which has therefore been suggested as
Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?
In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.
Vitamin D: a new player in kidney transplantation?
Theoretically, an optimal Vitamin D supplementation might favor operational tolerance and protect transplant recipients from the triad cardiovascular disease-cancer-infection, but more solid data are needed to confirm this and to set the optimal level of serum Vitamin D supplements in order to attain the best clinical outcome.
Detrimental Impact of Interferon-Based Regimens for Chronic Hepatitis C on Vitamin D/Parathyroid Hormone Homeostasis
An increase in plasma PTH occurs systematically during IFN treatment of HCV patients and cannot be prevented by vitamin D supplementation, and there is no statistical correlation between vitamin D and PTH blood levels.
Will vitamin d supplementation have a role in the treatment of patients with chronic hepatitis C?
  • P. Puri
  • Medicine, Biology
    Journal of clinical and experimental hepatology
  • 2012


Calcium‐parathyroid hormone‐vitamin D axis and metabolic bone disease in chronic viral liver disease
Background: The main process involved in hepatic osteodystrophy seems to be osteoporosis, but decreased 25‐hydroxylation of vitamin D might lead to osteomalacia and secondary hyperparathyroidism.
Vitamin D and the risk of acute allograft rejection following human liver transplantation
  • D. Bitetto, C. Fabris, P. Toniutto
  • Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2010
Background: Vitamin D may act as an immune modulator in experimental and human organ transplantation, but these data are yet to be confirmed in human liver transplantation (LT).
Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study
Vitamin D inadequacy and the severity of liver dysfunction move in parallel in patients with non-cholestatic chronic liver disease (CLD) and vitamin D assessment and replacement should be considered in the management of patients withNon-chollestatic CLD.
Shedding new light on vitamin D and fatty liver disease.
  • A. Geier
  • Medicine, Biology
    Journal of hepatology
  • 2011
Overview of general physiologic features and functions of vitamin D.
  • H. DeLuca
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2004
An overview of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D is provided and information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy is provided.
Assessment of bone metabolism and mineral density in chronic viral hepatitis.
The results suggest that chronic hepatitis B and C infections do not pose a risk for osteoporosis and low bone mineral density.
Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease.
  • L. Fisher, A. Fisher
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2007
Prospective study of bone mineral density and metabolism in patients with chronic hepatitis C during pegylated interferon α and ribavirin therapy
Osteopenia is detectable in a substantial proportion of CHC patients without established cirrhosis and Antiviral therapy leads to an on‐treatment increase of BMD, which may last in those patients who achieve a sustained virological response.