Review article: the clinical relevance of transient lower oesophageal sphincter relaxations in gastro-oesophageal reflux disease.

@article{Kessing2011ReviewAT,
  title={Review article: the clinical relevance of transient lower oesophageal sphincter relaxations in gastro-oesophageal reflux disease.},
  author={Boudewijn F. Kessing and Jos{\'e} M. Conchillo and Albert J Bredenoord and Andŕe Jpm Smout and Ad A M Masclee},
  journal={Alimentary pharmacology & therapeutics},
  year={2011},
  volume={33 6},
  pages={
          650-61
        }
}
BACKGROUND Transient lower oesophageal sphincter relaxations (TLOSR) are considered the physiological mechanism that enables venting of gas from the stomach and appear as sphincter relaxations that are not induced by swallowing. It has become increasingly clear that most reflux episodes occur during TLOSRs and therefore play a key role in gastro-oesophageal reflux disease (GERD). AIM To describe the current knowledge about TLOSRs and its clinical implications. METHODS Search of the… CONTINUE READING
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