Review article: the clinical pharmacology of proton pump inhibitors

@article{Sachs2006ReviewAT,
  title={Review article: the clinical pharmacology of proton pump inhibitors},
  author={G. Sachs and J. M. Shin and C. Howden},
  journal={Alimentary Pharmacology & Therapeutics},
  year={2006},
  volume={23}
}
Proton pump inhibitors inhibit the gastric H+/K+‐ATPase via covalent binding to cysteine residues of the proton pump. All proton pump inhibitors must undergo acid accumulation in the parietal cell through protonation, followed by activation mediated by a second protonation at the active secretory canaliculus of the parietal cell. 
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