Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance

  title={Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance},
  author={Miranda C E Lomer},
  journal={Alimentary Pharmacology \& Therapeutics},
  • M. Lomer
  • Published 1 February 2015
  • Medicine, Biology
  • Alimentary Pharmacology & Therapeutics
Food intolerance is non‐immunological and is often associated with gastrointestinal symptoms. 

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome

A FODMAP diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.

Diet Therapy in the Context of Chronic Pelvic Pain

The synergistic relationship between food and well-being is beyond doubt and there is now abundant evidence that comestibles enhance health through complex biological mechanisms.

Gastrointestinal symptoms, gastrointestinal bleeding and the role of diet in patients with autoimmune blistering disease: a survey of the International Pemphigus and Pemphigoid Foundation

Autoimmune blistering diseases are a group of severe mucocutaneous conditions that typically require the use of prolonged corticosteroids and immunosuppression. Properly managing associated

Food intolerance

The pathophysiology, clinical manifestations, diagnosis and treatment of the most common food intolerance have been presented and it may be argued that the lack of standardized tests accounts for the discrepancy between the perceived prevalence of food-related adverse effects and the actual prevalence of non-immunological reactions to food within these events.

[Food intolerances and the small intestine].

Analysis of the literature has confirmed in many patients with irritable bowel syndrome an etiotropic relationship with poor food tolerance and dictates the need for randomized studies to further study the pathogenetic mechanisms of increasing food tolerance under the influence of cytoprotective therapy.

Diagnosing and Treating Intolerance to Carbohydrates in Children

The most up-to-date research on intolerance to carbohydrates is examined, controversies relating to the diagnostic approach are discussed, including the role of molecular analysis, and new insights into modern management in the pediatric age are provided.

Mechanism-Oriented Therapy of Irritable Bowel Syndrome

This review has attempted to update scientific knowledge about the more relevant disease mechanisms involved and relate this more fundamental basis to the various treatment options available today.

[Food intolerances].

  • S. Bischoff
  • Medicine
    Deutsche medizinische Wochenschrift
  • 2014
FODMAP sensitivity has strong evidence supporting its mechanisms of increased osmotic activity and fermentation with the resulting distention leading to symptoms in those with visceral hypersensitivity, and reliable diagnostic biomarkers for all food intolerances result in an inability to target specific foods in the individual.

Food Allergies, Food Intolerances, and Carbohydrate Malabsorption

A case study of wheat-related disorders is presented in order to demonstrate the key differences between food allergy and intolerance and to discuss the approach to their diagnosis and treatment.



Food intolerance in functional bowel disorders

  • P. Gibson
  • Medicine
    Journal of gastroenterology and hepatology
  • 2011
This reviews aims to discuss strategies commonly applied in dietary change as an evidence‐based therapy in patients with functional bowel disorders.

Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disorders

The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) remains unclear.

Review article: lactose intolerance in clinical practice – myths and realities

A large number of people in the world have hypolactasia, but not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance.

The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study

The aim was to determine whether a low FODMAP diet improves symptoms in IBS patients.

The differential diagnosis of food intolerance.

The differential diagnosis of food intolerance is broad and a structured diagnostic algorithm with input from multiple clinical disciplines should be applied.

Alternative investigations for irritable bowel syndrome

The aim of the present study was to examine the alternative investigations that are advocated for the assessment of gastrointestinal disease and that are available through mainstream laboratories in Australia.

Irritable bowel syndrome: Role of food in pathogenesis and management

There is considerable interest in the potential roles of diet and food supplements in the therapy of IBS; for the most part, the evidence base for such recommendations remains slim though certain probiotics show considerable promise.

Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome

Reduction of short‐chain poorly absorbed carbohydrates (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome, and symptoms produced in response to diets that differed only in FODMAP content are compared.

Significance of salicylate intolerance in diseases of the lower gastrointestinal tract.

When presented with patients with chronic active disease who are suffering from these symptoms one should give greater thought to the possibility of salicylate intolerance, all the more as there are meaningful dietetic, diagnostic and therapeutic options available for these persons.

A dietary survey of patients with irritable bowel syndrome.

The dietary practices of Irish patients with IBS were examined to determine whether these practices increased their vulnerability to nutritional inadequacies, possibly exposing a considerable number to an increased risk of nutritional deficiency.