Review article: orofacial granulomatosis

  title={Review article: orofacial granulomatosis},
  author={Jo{\~a}o Domingos Barbosa Carneiro Le{\~a}o and Tim A Hodgson and Crispian M Scully and S R Porter},
  journal={Alimentary Pharmacology \& Therapeutics},
Orofacial granulomatosis is an uncommon clinicopathological entity describing patients who have oral lesions characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other orofacial features, who on lesional biopsy have lymphoedema and non‐caseating granulomas. The aetiology of oral lesions with non‐caseating granulomas includes oral Crohn's disease (some patients with oral lesions will develop typical bowel symptoms of Crohn's disease in ensuing months to… 

Orofacial Granulomatosis of the Upper Lip: A Case Report

The etiology of oral lesions with non-caseating granulomas includes oral Crohn’s tooth associated infections, sarcoidosis and food or contact allergies.

Clinicopathological diagnosis of orofacial granulomatosis

A 61-year-old woman with recurrent ulcerations and swellings in her oral mucosa was diagnosed as orofacial granulomatosis based upon clinicopathological correlation after exclusion of other granULomatous diseases and showed a favorable response to systemic corticosteroid treatment.

Orofacial granulomatosis and chronic tonsillitis.

A case of OFG is presented as the pathologic mechanism in chronic persistent tonsillitis, and a number of clinical and histologic similarities between OFG and these conditions are presented.

Orofacial granulomatosis of the lower lip and cheek: report of a case.

Orofacial Granulomatosis: Report of Two Cases with Gingival Onset

Though infrequent, orofacial granulomatosis with gingival involvement should be considered in the differential diagnosis of hyperplastic gingivitis of uncertain origin.

Coexisting orofacial granulomatosis with discoid lupus erythematosus: Report of a rare case

The rare case of a 15-year-old patient, suffering from OFG and discoid lupus erythematosus is reported; this coexistence of two such rare entities together hardly finds a mention in the literature.

Intralymphatic Granulomas as a Pathogenic Factor in Cheilitis Granulomatosa/Melkersson–Rosenthal Syndrome: Report of a Case With Immunohistochemical and Molecular Studies

It is demonstrated, by immunohistochemical studies, the lymphatic nature of the vessels affected by the granulomatous process, namely, intralymphatic granulomas, which may be the cause of the tissue edema.

Orofacial granulomatosis as a presenting feature of Crohn's disease

This case highlights that orofacial granulomatosis may precede the onset of intestinal Crohn's disease.

Childhood and adolescent orofacial granulomatosis is strongly associated with Crohn's disease and responds to intralesional corticosteroids

The literature is reviewed and the epidemiological association between childhood orofacial granulomatosis and Crohn's disease is discussed, as well as various treatment options, and a treatment protocol that was efficacious and well tolerated in all patients is proposed.



Orofacial granulomatosis as initial manifestation of Crohn's disease: a report of two cases.

Two rare cases are reported in which swelling of the lips and cheeks were the initial symptoms that finally led to the diagnosis of Crohn's disease.

Cheilitis granulomatosa: overview of 13 patients with long‐term follow‐up – results of management

Although a relationship has been proposed between Melkersson–Rosenthal syndrome (and the monosymptomatic form, cheilitis granulomatosa) and Crohn’s disease on the basis of the orofacial swelling and similar histology, several studies of Melkerson– Rosenthal syndrome have not found an association with Crohn's disease.

Orofacial Granulomatosis as the Initial Presentation of Crohn’s Disease in an Adolescent

It is concluded that OFG may be under- or misdiagnosed since the clinical manifestation may be misleading and its course is independent of or even preceding CD.

Orofacial granulomatosis: report of two Nigerian cases.

  • O. Odukoya
  • Medicine
    The Journal of tropical medicine and hygiene
  • 1994
Two cases of orofacial granulomatosis are reported in Nigeria, one of which is that of a 24-year-old Nigerian female, who presented with a complete form of Melkersson-Rosenthal syndrome, and the other of a 32- year-old male who gave a history of intolerance to some food items.

Granulomatous cheilitis: a study of six cases.

Clinical records of six patients presenting with Granulomatous cheilitis were examined and treated in the Department of Oral Medicine and Pathology of the Dental School of Aristotle University of Thessaloniki (Greece) during a 16-year period and a persistent swelling of the lower lip was recorded.

Erythematous Swelling of the Lip Associated with Sjögren's Syndrome and Mimicking Cheilitis Granulomatosa

This is the first patient in whom annular erythema associated with Sjögren's syndrome involved only the upper lip and produced clinical features simulating cheilitis granulomatosa.

Orofacial granulomatosis with gingival onset.

Early diagnosis of OFG is a crucial step to prevent and cure its unsightly sequelae and sometimes avoid progression of systemic potentially life-threatening OFG-related diseases.

Granulomatous disorders of the oral mucosa.

  • J. Eveson
  • Medicine
    Seminars in diagnostic pathology
  • 1996
The clinical and pathologic features of some of the more common oral granulomatous disorders are considered, including idiopathic conditions, foreign body lesions, and infectious lesions.

Thalidomide for the treatment of recalcitrant oral Crohn's disease and orofacial granulomatosis.

Thalidomide should be considered an effective therapy for the short-term treatment of severe orofacial granulomatosis in appropriately counseled patients.