Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease.

@article{Allgayer2003ReviewAM,
  title={Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease.},
  author={Hubert Allgayer},
  journal={Alimentary pharmacology & therapeutics},
  year={2003},
  volume={18 Suppl 2},
  pages={10-4}
}
A series of epidemiological, experimental and preliminary clinical trials strongly suggest that mesalazine or 5-aminosalicyclic acid (5-ASA) may have antineoplastic and potentially prophylactic chemopreventive properties. It is assumed that mesalazine may have similar genetic and molecular targets as nonsteroidal anti-inflammatory drugs (NSAIDs), which is further supported by its close similarity with aspirin, differing only in its structure by the presence of an amino group at position 5 of… CONTINUE READING

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