Review article: inflammation‐related promotion of gastrointestinal carcinogenesis – a perigenetic pathway

@article{Tsuji2003ReviewAI,
  title={Review article: inflammation‐related promotion of gastrointestinal carcinogenesis – a perigenetic pathway},
  author={S. Tsuji and N. Kawai and M. Tsujii and S. Kawano and M. Hori},
  journal={Alimentary Pharmacology & Therapeutics},
  year={2003},
  volume={18}
}
  • S. Tsuji, N. Kawai, +2 authors M. Hori
  • Published 2003
  • Biology, Medicine
  • Alimentary Pharmacology & Therapeutics
  • Chronic inflammation has been reported to accelerate neoplasmas in gastrointestinal tract. Certain bacteria including Helicobacter pylori directly interact with host cells, induce proinflammatory cytokines and stimulate production of free radicals. Free radicals cause mutations in target cells so that neoplastic clones are established. Accumulation of such genetic alterations may cause malignant transformation of some established clones. In addition, inflammatory alterations may promote growth… CONTINUE READING
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