Review article: gastroduodenal bicarbonate secretion.

@article{Hogan1994ReviewAG,
  title={Review article: gastroduodenal bicarbonate secretion.},
  author={Daniel L. Hogan and Mark A. Ainsworth and Jon I. Isenberg},
  journal={Alimentary pharmacology & therapeutics},
  year={1994},
  volume={8 5},
  pages={
          475-88
        }
}
The gastroduodenal epithelium is covered by an adherent mucus layer into which bicarbonate is secreted by surface epithelial cells. This mucus-bicarbonate barrier is an important first line of defence against damage by gastric acid and pepsin, and has been demonstrated in all species including human. Similar to gastric acid secretion, regulation of gastric and duodenal bicarbonate secretion can be divided into three phases: cephalic, gastric and duodenal. In humans, sham-feeding increases… CONTINUE READING
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