Review article: diabetes and atherosclerosis--running on a common road.

  title={Review article: diabetes and atherosclerosis--running on a common road.},
  author={Massimo Federici and Renato Lauro},
  journal={Alimentary pharmacology & therapeutics},
  volume={22 Suppl 2},
Insulin resistance accounts for glucotoxicity observed in diabetes and atherosclerotic disease. Glucotoxicity depends from the shift of glucose metabolism from the glycolytic pathway to minor forms of glucose metabolism, including sorbitol, hexosamine and AGE pathways. These pathways increase oxidative stress and/or block insulin signalling so leading to a further decline of insulin action. A genetic defect of insulin action (the g972R Insulin Receptor Substrate 1 variant) may sustain… CONTINUE READING


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