Review article: diabetes, genetics and ethnicity

  title={Review article: diabetes, genetics and ethnicity},
  author={Lucia Carulli and S. Rondinella and Silvia Lombardini and I. Canedi and Paola Loria and Nicola Carulli},
  journal={Alimentary Pharmacology \& Therapeutics},
The prevalence of insulin resistance and diabetes has increased in the past decades at an alarming rate in all Western countries and in those countries which are adopting a ‘western life style’. This trend suggests the impact of environmental factors such as diet, obesity and physical activity on the pathogenesis of diabetes. However it is known that the prevalence and variation of prevalence, as consequence of environmental changes, it is different in various ethnic groups. Studies conducted… 

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The peroxisome proliferator‐activated receptor gamma (PPARγ) and calpain‐10 (CAPN10) genes have recently been identified as T2DM susceptibility genes, and the lessons learnt are helping to shape future strategies to search for additional susceptibility genes in type 2 diabetes mellitus and insulin resistance.

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