Review article: cardiac adverse effects of gastrointestinal prokinetics.

@article{Tonini1999ReviewAC,
  title={Review article: cardiac adverse effects of gastrointestinal prokinetics.},
  author={Marcello Tonini and Fabrizio De Ponti and Amalia Di Nucci and Francesca Crema},
  journal={Alimentary pharmacology & therapeutics},
  year={1999},
  volume={13 12},
  pages={1585-91}
}
Gastrointestinal prokinetics, such as metoclopramide, cisapride and levosulpiride, are widely used for the management of functional gut disorders. Recently, several studies have shown that cisapride (a partial 5-HT4 receptor agonist) can induce dose-dependent cardiac adverse effects, including lengthening of the electrocardiographic QT interval, syncopal episodes and ventricular dysrhythmias. Until recently, it was not clear whether these effects were dependent on 5-HT4 receptor activation or… CONTINUE READING
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