Review article: How useful are the rodent animal models of gastric adenocarcinoma?

@article{Pritchard2004ReviewAH,
  title={Review article: How useful are the rodent animal models of gastric adenocarcinoma?},
  author={D. Mark Pritchard and S. M. C. Przemeck},
  journal={Alimentary pharmacology & therapeutics},
  year={2004},
  volume={19 8},
  pages={841-59}
}
Gastric cancer is the second most common cause of cancer-related mortality world-wide. In most cases, it develops via the pre-malignant stages of atrophic gastritis, intestinal metaplasia and dysplasia, following Helicobacter pylori infection of susceptible individuals. A number of rodent models have recently provided valuable insights into the host, bacterial and environmental factors involved in gastric carcinogenesis. Wild-type rodents do not develop gastric adenocarcinoma, but early studies… CONTINUE READING