Review article: Amphetamines and related drugs of abuse

@article{Greene2008ReviewAA,
  title={Review article: Amphetamines and related drugs of abuse},
  author={Shaun L Greene and Fergus Kerr and George Braitberg},
  journal={Emergency Medicine Australasia},
  year={2008},
  volume={20}
}
Acute amphetamine toxicity is a relatively common clinical scenario facing the Australasian emergency medicine physician. Rates of use in Australasia are amongst the highest in the world. Clinical effects are a consequence of peripheral and central adrenergic stimulation producing a sympathomimetic toxidrome and a spectrum of central nervous system effects. Assessment aims to detect the myriad of possible complications related to acute amphetamine exposure and to institute interventions to… 
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References

SHOWING 1-10 OF 101 REFERENCES
Amphetamine toxicity: experience with 127 cases.
Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management.
TLDR
An overview of MDMA pharmacology and acute toxicity will be given followed by a plan for clinical management of patients with acute MDMA toxicity.
Use of diazepam in hallucinogenic drug crises.
TLDR
Diazepam was used in the treatment of hallucinogenic-drug crises in 69 patients; 67 responded well and seems to be suitable in supportive chemotherapy of "illusinogenic" drug crises.
Hyponatraemic states following 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') ingestion.
TLDR
MDMA can cause life-threatening hyponatraemic encephalopathy when accompanied by excessive fluid ingestion, and the mechanism involves inappropriate secretion of antidiuretic hormone.
A case of MAO inhibitor/MDMA interaction: agony after ecstasy.
TLDR
This case suggests that MDMA can cause significant toxicity in patients taking MAO inhibitors, and shares structural and pharmacologic features with other agents capable of causing this interaction.
Amphetamine derivative fatalities in South Australia--is "Ecstasy" the culprit?
TLDR
The number of deaths due to amphetamine derivatives apparently due to substitution of PMA for MDMA (Ecstasy) have recently increased markedly in Adelaide, and potential users are warned that PMA has a much higher rate of lethal complications than other designer drugs, and that no guarantee can be made that tablets sold as Ecstasy are not PMA.
Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
Central nervous system stimulants.
  • A. George
  • Psychology
    Bailliere's best practice & research. Clinical endocrinology & metabolism
  • 2000
Three major types of CNS stimulant are currently abused in sport: amphetamine, cocaine and caffeine. Each drug type has its own characteristic mechanism of action on CNS neurones and their associated…
The serotonin syndrome and its treatment
  • P. Gillman
  • Medicine, Psychology
    Journal of psychopharmacology
  • 1999
TLDR
There is some evidence suggesting the efficacy of chlorpromazine and cyproheptadine in the treatment of serotonin syndrome, but the evidence for cypro heptamines is less substantial than that for chlor Promazine, perhaps because the dose necessary to ensure blockade of brain 5-HT2receptors is higher than that used in the cases reported to date.
Dantrolene Use in 3 , 4-Methylenedioxymethamphetamine ( “ Ecstasy ” ) – Mediated Hyperthermia
TLDR
It has now been shown that occult lesions may be detected in asymptomatic patients using readily available radiographic screening methods and that noninvasive interventions may be undertaken to reverse or arrest the progression of these masses without additional surgery or catheter explantation.
...
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