Review article: Acute serious and fatal reactions to contrast media: our current understanding.

@article{Morcos2005ReviewAA,
  title={Review article: Acute serious and fatal reactions to contrast media: our current understanding.},
  author={Sameh K. Morcos},
  journal={The British journal of radiology},
  year={2005},
  volume={78 932},
  pages={686-93}
}
Serious or fatal reactions to a contrast medium (CM) are unpredictable but fortunately rare. History of serious reaction to CM, bronchial asthma or multiple allergies increases the incidence of serious reactions by a factor of 5. Serious or fatal reaction to CM could be due to direct effect on basophils and mast cells or IgE mediated (type 1 hypersensitivity reaction). Activation of the kinin system leading to the formation of bradykinin could also be involved. Complement activation is unlikely… CONTINUE READING