Study selection and analysis: Randomised controlled trials examining St John’s Wort in people with depression, with participants diagnosed using the Hamilton Rating Scale for Depression (HAM-D) and using uniform criteria to measure treatment success (that is, 50% reduction in baseline HAM-D score) were eligible. Exclusions: trials using St John’s Wort in combination with other herbal preparations or to target psychiatric conditions other than depression. Two meta-analyses were conducted. One was a reproduction of the meta-analysis published in 2001 that included 15 studies (Meta-15). The other was an extension of the Meta-15 that included three subsequently published studies (Meta-18). Funnel plots, Begg’s rank correlations, Egger’s regressions, trim and fill methods, and meta-regressions were used to compare the Meta-15 and Meta-18 results.