• Corpus ID: 26822349

Review-Epigenetic therapy for cancer.

  title={Review-Epigenetic therapy for cancer.},
  author={Mohammad Saleem and Khizar Abbas and Maria Manan and Hira Ijaz and Bilal Ahmed and Muhammad Ali and Muhammad Hanif and Ammad Ahmad Farooqi and M. Qadir},
  journal={Pakistan journal of pharmaceutical sciences},
  volume={28 3},
Epigenetics means the study of alterations in the genetic material that affect the phenotype but does not affect the genotype. Epigenetics cause alterations in cell properties, which are inherited; but it does not cause alterations in DNA sequence. Epigenetic mediated silencing of gene is of four types, which are DNA methylation, histone deacetylation, RNA associated silencing and Genomic imprinting. Other factors (environmental and xenobiotics) can also cause gene silencing but DNA… 
Epigenetic therapies in patients with solid tumors: Focus on monotherapy with deoxyribonucleic acid methyltransferase inhibitors and histone deacetylase inhibitors
A brief overview of the mechanisms of action and targets for novel epi-drugs, focusing on their potential clinical applications in patients with solid tumors, resistant to standard oncology treatments is provided.
Genetic Variants Associated with DNA methylation
The progress about genetic variants associated with DNA methylation is discussed, including the relationship between genetic variation,DNA methylation and complex disease, the association study of DNAmethylation quantitative trait loci and the expression quantitative traits loci, as well as identification of allele specific methylation that will be help for understanding the regulatory mechanisms of genetic variation and epigenetic modification.
Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma
The evidence for triggering GBM cell death by targeting telomerase and the ALT pathway is reviewed, with an extra focus on a plant-derived compound, butylidene phthalide (BP), which may be a promising novel anticancer compound with good potential for clinical applications.
5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells
It is suggested that DAPK1 and MGMT methylation can serve as sensitive diagnostic biomarkers and therapeutic targets for CMGTs and 5-azacytidine also could be a potential therapeutic candidate forCMGTs.
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL.
It is concluded that a higher prevalence of methylation of PTPL1, PTPN6, DAPK and p16 occur in DLBCL and this data highlights 5-azacytidine as a potential therapeutic candidate forDLBCL.
ACCEPTED MANUSCRIPT Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma
It is shown that epigenetic modification by methylation is associated with decreased genomic translation of Rad51, the key protein that confers genomic stability in renal carcinoma.
Immunohistochemical Analysis of Epigenetic Markers in Cervical Pathologies Associated with Human Papillomavirus Infection
The clinicopathologic characteristics and immunohistochemical features of 185 patients with cervical pathologies associated with human papillomavirus infection were examined and strong correlations of these factors with cervical Pathologies including malignancies were identified.