• Corpus ID: 26822349

Review-Epigenetic therapy for cancer.

@article{Saleem2015ReviewEpigeneticTF,
  title={Review-Epigenetic therapy for cancer.},
  author={Mohammad Saleem and Khizar Abbas and Maria Manan and Hira Ijaz and Bilal Ahmed and Muhammad Ali and Muhammad Hanif and Ammad Ahmad Farooqi and M. Qadir},
  journal={Pakistan journal of pharmaceutical sciences},
  year={2015},
  volume={28 3},
  pages={
          1023-32
        }
}
Epigenetics means the study of alterations in the genetic material that affect the phenotype but does not affect the genotype. Epigenetics cause alterations in cell properties, which are inherited; but it does not cause alterations in DNA sequence. Epigenetic mediated silencing of gene is of four types, which are DNA methylation, histone deacetylation, RNA associated silencing and Genomic imprinting. Other factors (environmental and xenobiotics) can also cause gene silencing but DNA… 
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ACCEPTED MANUSCRIPT Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma
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It is shown that epigenetic modification by methylation is associated with decreased genomic translation of Rad51, the key protein that confers genomic stability in renal carcinoma.
Immunohistochemical Analysis of Epigenetic Markers in Cervical Pathologies Associated with Human Papillomavirus Infection
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The clinicopathologic characteristics and immunohistochemical features of 185 patients with cervical pathologies associated with human papillomavirus infection were examined and strong correlations of these factors with cervical Pathologies including malignancies were identified.
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