Review Cell Biology of Arterial Proteogiycans


Although proteogiycans constitute a minor component of vascular tissue, these molecules have been shown to Influence a number of arterial properties such as vlscoelastlclty, permeability, llpkJ metabolism, hemostasls, and thrombosis. A hallmark of early and late atherosclerosis is the accumulation of proteogiycans In the Intlmal lesions. Yet, it Is not clear why this accumulation occurs. This article reviews the classes of proteogiycans synthesized by the two major cell types of the arterial wall—the endotheliai and smooth muscle cell. Detailed consideration is then given to the modulation of proteoglycan metabolism and the role that proteogiycans play In a number of cellular events such as adhesion, migration, and proliferation—Important processes In both the development and the pathogenesls of blood vessels. Last, the Involvement of proteogiycans in two critical vascular wall processes—hemostasls and llpld metabolism—Is reviewed, because these events pertain to atherogenesls. This review emphasizes the importance of proteogiycans In regulating several key events In normal and pathophyslological processes In the vascular tissue. (Arteriosclerosis 9:1-20, January/February 1989)

Cite this paper

@inproceedings{Wight2005ReviewCB, title={Review Cell Biology of Arterial Proteogiycans}, author={Thomas N Wight}, year={2005} }