Review Bench-to-bedside review: Understanding genetic predisposition

  title={Review Bench-to-bedside review: Understanding genetic predisposition},
  author={Nicole Maca-Meyer and Lina I P{\'e}rez-M{\'e}ndez and Carlos Flores},
Sepsis is a complex syndrome that develops when the initial, appropriate host response to an infection becomes amplified, and is then dysregulated. Among other factors, the innate immune system is of central importance to the early containment of infection. Death from infection is strongly heritable in human populations. Hence, genetic variations that disrupt innate immune sensing of infectious organisms could explain the ability of the immune system to respond to infection, the diversity of… CONTINUE READING