Review: transport of tRNA out of the nucleus-direct channeling to the ribosome?

@article{Grohans2000ReviewTO,
  title={Review: transport of tRNA out of the nucleus-direct channeling to the ribosome?},
  author={Helge Gro\sshans and George Simos and Edward C Hurt},
  journal={Journal of structural biology},
  year={2000},
  volume={129 2-3},
  pages={288-94}
}
Although tRNA was the first substrate whose export from the nuclei of eukaryotic cells had been shown to be carrier-mediated and active, it has only been in the last 2 years that the first mechanistic details of this nucleocytoplasmic transport pathway have begun to emerge. A member of the importin/karyopherin beta superfamily, Los1p in yeast and Xpo-t in vertebrates, has been shown to export tRNA in cooperation with the small GTPase Ran (Gsp1p) from the nucleus into the cytoplasm, where tRNA… CONTINUE READING

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