Review: systemic effects of femoral nailing: from Küntscher to the immune reactivity era.

  title={Review: systemic effects of femoral nailing: from K{\"u}ntscher to the immune reactivity era.},
  author={Peter V Giannoudis and Hans Christoph Pape and Andrew P. Cohen and Christian Krettek and Raymond Malcolm Smith},
  journal={Clinical orthopaedics and related research},
Intramedullary nailing is the preferred treatment for stabilizing femoral diaphyseal fractures. Despite the superior biomechanical advantages over other implants, its use especially in some selected groups of patients, has been questioned because of possible harmful systemic effects of intramedullary reaming. The lung seems to be the primary target for fat embolization and for mediated effects by inflammatory reactions. The latter are initiated in the immediate aftermath after injury, and… CONTINUE READING