Review: properties and assembly mechanisms of ND10, PML bodies, or PODs.

  title={Review: properties and assembly mechanisms of ND10, PML bodies, or PODs.},
  author={G. Maul and Dmitri G. Negorev and Peter Bell and Alexander M Ishov},
  journal={Journal of structural biology},
  volume={129 2-3},
Nuclear domain 10 (ND10), also referred to as PML bodies or PODs, are discrete interchromosomal accumulations of several proteins including PML and Sp100. We describe here developments in the visualization of ND10 and the mechanism of ND10 assembly made possible by the identification of proteins that are essential for this process using cell lines that lack individual ND10-associated proteins. PML is critical for the proper localization of all other ND10-associated proteins under physiological… CONTINUE READING
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