Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology.

@article{Lee2013ReviewEM,
  title={Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology.},
  author={Daniel C. Lee and Justin Rizer and Jerry B. Hunt and M-L B Selenica and Marcia N Gordon and David Morgan},
  journal={Neuropathology and applied neurobiology},
  year={2013},
  volume={39 1},
  pages={
          69-85
        }
}
The inflammation hypothesis of Alzheimer's pathogenesis has directed much scientific effort towards ameliorating this disease. The development of mouse models of amyloid deposition permitted direct tests of the proposal that amyloid-activated microglia could cause neurodegeneration in vivo. Many approaches to manipulating microglial activation have been applied to these mouse models, and are the subject of this review. In general, these results do not support a direct neuricidal action of… CONTINUE READING
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